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History of Diazepam

Given diazepam’s long history as an effective and common medication for various conditions, recent advances in the formulation and administration of the drug include developing and approving an auto-injectable formulation for the speedy treatment of uncontrolled seizures by the US Food and Drug Administration in 2015-2016. When diazepam, a proven successful treatment for acute repeated seizures, is combined with a subcutaneous auto-injector that is fast and easy to use, the possibility for complete, continuous drug absorption and rapid onset of effect is increased. As a result, this latest research is a significant addition to the arsenal of epilepsy sufferers’ rescue therapies.

Indication

Diazepam is beneficial in the symptomatic treatment of mild to moderate anxiety in situations influenced by tension, restlessness, agitation, fear, or aggressiveness, such as psychoneurosis, anxiety reactions owing to stress, and anxiety states with somatic expression.

Mechanism of action

Diazepam is a benzodiazepine tranquilizer that works as an anticonvulsant, sedative, muscle relaxant, and amnesic.

Diazepam and other benzodiazepines bind to receptors throughout the brain and spinal cord. The inhibitory effects of gamma-aminobutyric acid are enhanced by this binding (GABA).

Sleep induction is one of GABA’s activities in the CNS. Hypnosis, memory, anxiety, epilepsy, and neural excitability are all controlled by this enzyme.

Absorption

It is considered that diazepam is promptly and thoroughly absorbed from the gastrointestinal system after oral administration because >90% of diazepam is absorbed, and the typical time to reach peak plasma concentrations is 1–1.5 hours, with a span of 0.25 to 2.5 hours.

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